In 1837 Bishop Simon Brute decided that the Catholic congregation in Shelby County had grown enough to merit its own resident priest. Father Vincent Bacquelin arrived on horseback to fill that role, and he spent two years offering Masses in a log cabin home owned by the Worland family. By September of 1838 work had begun to build a church on two acres of land donated by Thomas Worland. By October of 1839 the church was dedicated to the patron St. Vincent de Paul, and the first Mass was celebrated there. Many priests have followed and ministered at St. Vincent de Paul, the first Catholic Church of Shelby County.
| Father Vincent Bacquelin | 1837 - 1846 |
| Father John F. Ryan | 1846 |
| Father John McDermott | 1847 |
| Father Patrick Murphy | 1847 - 1848 |
| Father John Guegen | 1848 - 1853 |
| Father Daniel Molony | 1853 - 1855 |
| Father Edward Martinovic | 1855 - 1863 |
| Father John Paul Gillig | 1863 - 1867 |
| Father William Doyle | 1867 - 1868 |
| Father Francis Joseph Rudolph | 1868 - 1881 |
| Father Francis Torbeck | 1881 - 1886 |
| Father Michael Guthneck | 1886 - 1890 |
| Father Joseph Hegger | January 1891 |
| Father Ferdinand Hundt | 1891 - 1892 |
| Father Gustave Ginnsz | 1892 - 1896 |
| Father Aloysius Danehoeffer | 1896 - 1898 |
| Father Charles Stricker | 1898 |
| Father Joseph Hass | 1898 - 1899 |
| Father Joseph T. Bauer | 1899 - 1906 |
| Father Frederic Ketter | 1906 - 1918 |
| Father Cornelius Bosler | 1918 - 1923 |
| Father Francis Wolf | 1923 - 1926 |
| Father Joseph F. Duffey | 1926 - 1928 |
| Father Thomas Hoffman | 1928 |
| Father Pierce Dixon | 1928 - 1932 |
| Father Andrew Bastnagel | 1932 - 1934 |
| Father Bernard Riedford | 1934 - 1938 |
| Father Henry Trapp | 1938 - 1941 |
| Father John Bankowski | 1941 - 1949 |
| Father Anthony Seger | 1949 - 1973 |
| Father Joseph Laugel | 1973 - 1979 |
| Father James R. Dede | 1979 - 1996 |
| Father Paul Landwerlen | 1996 - 2013 |
| Father Aaron Pfaff | 2013 - 2016 |
| Father Martin Rodriguez | 2016 - 2017 |
| Father Joseph Newton | 2017 |
| Father Michael Keucher | 2017 - current |